Biography

Andrea Burden obtained her Bachelor of Science degree in Psychology and a Master of Arts in Criminology at the University of Toronto.

Following her Master’s program Andrea enrolled in a Master of Science in the faculty of pharmaceutical sciences at the University of Toronto, with focus in pharmacoepidemiology (drug safety and effectiveness). Following 18-months in the MSc program, she transferred to the PhD stream where her research focus was on osteoporosis medication adherence.

In 2014, she received a CIHR fellowship (2015-2017) to conduct her postdoctoral research in the Netherlands, where her focus is on diabetes and bone health and rheumatoid arthritis. Since 2018 she is an Assistant Professor at ETH Zurich where she holds the chair in pharmacoepidemiology at the Institute of Pharmaceutical Sciences.

Andrea has experience analysing some of the world’s most prestigious healthcare databases from Canada, the UK, Denmark and the Netherlands.
Her primary research line examines the safety and effectiveness of medications in chronic disease management, with particular focus on the relationship between metabolic (diabetes and obesity) and musculoskeletal (osteoporosis and rheumatoid arthritis) diseases.

List of 5 Best Publications

• Fracture definitions in observational osteoporosis drug effects studies that leverage healthcare administrative (claims) data: a scoping review

  https://pubmed.ncbi.nlm.nih.gov/35578134/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Identification of novel off targets of baricitinib and tofacitinib by machine learning with a focus on thrombosis and viral infection

  https://pubmed.ncbi.nlm.nih.gov/35551258/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Comment on: Paradoxically protective effect of glucocorticoids on bone mass and fragility fracture in a large cohort: a cross-sectional study

  https://pubmed.ncbi.nlm.nih.gov/35531047/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Corrigendum: When to Start and Stop Bone-Protecting Medication for Preventing Glucocorticoid-Induced Osteoporosis

  https://pubmed.ncbi.nlm.nih.gov/35370960/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Interruptions of biological and targeted synthetic disease-modifying antirheumatic drugs in rheumatoid arthritis: a descriptive cohort study assessing trends in patient characteristics in Switzerland

  https://pubmed.ncbi.nlm.nih.gov/35292498/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Biological Disease-Modifying Antirheumatic Drugs and Osteoporotic Fracture Risk in Patients with Rheumatoid Arthritis: A Danish Cohort Study

  https://pubmed.ncbi.nlm.nih.gov/35134369/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Bone fragility in diabetes: novel concepts and clinical implications

  https://pubmed.ncbi.nlm.nih.gov/35101185/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Drug Triggers and Clinic of Acute Generalized Exanthematous Pustulosis (AGEP): A Literature Case Series of 297 Patients

  https://pubmed.ncbi.nlm.nih.gov/35054090/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• When to Start and Stop Bone-Protecting Medication for Preventing Glucocorticoid-Induced Osteoporosis

  https://pubmed.ncbi.nlm.nih.gov/34975756/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Fracture Patterns in Type 1 and Type 2 Diabetes Mellitus: A Narrative Review of Recent Literature

  https://pubmed.ncbi.nlm.nih.gov/34931295/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Observational cross-sectional case study of toxicities of antifungal drugs

  https://pubmed.ncbi.nlm.nih.gov/34896339/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Prediction of sustained biologic and targeted synthetic DMARD-free remission in rheumatoid arthritis patients

  https://pubmed.ncbi.nlm.nih.gov/34888435/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• The association between bariatric surgery and cataract: a propensity score-matched cohort study

  https://pubmed.ncbi.nlm.nih.gov/34863672/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• The association of bariatric surgery and Dupuytren's disease: a propensity score-matched cohort study

  https://pubmed.ncbi.nlm.nih.gov/34851767/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Community Pharmacist-Administered COVID-19 Vaccinations: A Pilot Customer Survey on Satisfaction and Motivation to Get Vaccinated

  https://pubmed.ncbi.nlm.nih.gov/34835251/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• External validation of the PAR-Risk Score to assess potentially avoidable hospital readmission risk in internal medicine patients

  https://pubmed.ncbi.nlm.nih.gov/34813625/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Increased radiographic progression of distal hand osteoarthritis occurring during biologic DMARD monotherapy for concomitant rheumatoid arthritis

  https://pubmed.ncbi.nlm.nih.gov/34702319/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• A Network Analysis of Drug Combinations Associated with Acute Generalized Exanthematous Pustulosis (AGEP)

  https://pubmed.ncbi.nlm.nih.gov/34640505/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Clinical Relevance of a 16-Gene Pharmacogenetic Panel Test for Medication Management in a Cohort of 135 Patients

  https://pubmed.ncbi.nlm.nih.gov/34361984/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Comparison of Psoriatic Arthritis and Rheumatoid Arthritis Patients across Body Mass Index Categories in Switzerland

  https://pubmed.ncbi.nlm.nih.gov/34300360/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Low-dose oral glucocorticoid therapy and risk of osteoporotic fractures in patients with rheumatoid arthritis: a cohort study using the Clinical Practice Research Datalink

  https://pubmed.ncbi.nlm.nih.gov/34255815/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Assessment of minor health disorders with decision tree-based triage in community pharmacies

  https://pubmed.ncbi.nlm.nih.gov/34244075/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Thiazolidinediones and Glucagon-Like Peptide-1 Receptor Agonists and the Risk of Nonalcoholic Fatty Liver Disease: A Cohort Study

  https://pubmed.ncbi.nlm.nih.gov/34129693/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Response to: 'Correspondence on 'Concomitant use of oral glucocorticoids and proton pump inhibitors and risk of osteoporotic fractures among patients with rheumatoid arthritis: a population-based cohort study' by Gong and Zhang and Lin et al

  https://pubmed.ncbi.nlm.nih.gov/34039619/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Cardiovascular Safety Profile of Romosozumab: A Pharmacovigilance Analysis of the US Food and Drug Administration Adverse Event Reporting System (FAERS)

  https://pubmed.ncbi.nlm.nih.gov/33924496/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Determinants of treatment modification before and after implementation of the updated 2015 NICE guideline on type 2 diabetes: A retrospective cohort study

  https://pubmed.ncbi.nlm.nih.gov/33894280/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Global adverse events reported for direct-acting antiviral therapies for the treatment of hepatitis C: an analysis of the World Health Organization VigiBase

  https://pubmed.ncbi.nlm.nih.gov/33883523/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Primary and secondary non-response: in need of operational definitions in observational studies

  https://pubmed.ncbi.nlm.nih.gov/33883161/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Duration of Bisphosphonate Drug Holidays in Osteoporosis Patients: A Narrative Review of the Evidence and Considerations for Decision-Making

  https://pubmed.ncbi.nlm.nih.gov/33803095/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Response to: 'Correspondence on 'Concomitant use of oral glucocorticoids and proton pump inhibitors and risk of osteoporotic fractures among patients with rheumatoid arthritis: a population-based cohort study'' by Zheng

  https://pubmed.ncbi.nlm.nih.gov/33558257/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Renal ischemic adverse drug events related to tranexamic acid in women of child-bearing age: an analysis of pharmacovigilance data

  https://pubmed.ncbi.nlm.nih.gov/33341923/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Concomitant use of oral glucocorticoids and proton pump inhibitors and risk of osteoporotic fractures among patients with rheumatoid arthritis: a population-based cohort study

  https://pubmed.ncbi.nlm.nih.gov/33310727/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Osteoporosis case ascertainment strategies in European and Asian countries: a comparative review

  https://pubmed.ncbi.nlm.nih.gov/33305343/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Implementation and management outcomes of pharmacogenetic CYP2C19 testing for clopidogrel therapy in clinical practice

  https://pubmed.ncbi.nlm.nih.gov/33242107/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• National Poison Center Calls Before vs After Availability of High-Dose Acetaminophen (Paracetamol) Tablets in Switzerland

  https://pubmed.ncbi.nlm.nih.gov/33112400/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Incidence of Differentiation Syndrome Associated with Treatment Regimens in Acute Myeloid Leukemia: A Systematic Review of the Literature

  https://pubmed.ncbi.nlm.nih.gov/33081000/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Community pharmacist-administered seasonal influenza vaccination: a national customer survey

  https://pubmed.ncbi.nlm.nih.gov/32999727/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Movement disorders and use of risperidone and methylphenidate: a review of case reports and an analysis of the WHO database in pharmacovigilance

  https://pubmed.ncbi.nlm.nih.gov/32621088/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Thromboembolic Safety Reporting of Tofacitinib and Baricitinib: An Analysis of the WHO VigiBase

  https://pubmed.ncbi.nlm.nih.gov/32533433/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Medication as a risk factor for hospitalization due to heart failure and shock: a series of case-crossover studies in Swiss claims data

  https://pubmed.ncbi.nlm.nih.gov/32270213/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Drug utilization in the Maastricht Study: A comparison with nationwide data

  https://pubmed.ncbi.nlm.nih.gov/31895787/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Pharmacoepidemiology and Big Data Analytics: Challenges and Opportunities when Moving towards Precision Medicine

  https://pubmed.ncbi.nlm.nih.gov/31883553/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• The Association of Oral Bisphosphonate Use With Mortality Risk Following a Major Osteoporotic Fracture in the United Kingdom: Population-Based Cohort Study

  https://pubmed.ncbi.nlm.nih.gov/31839557/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Association between osteoporosis and statins therapy: the story continues

  https://pubmed.ncbi.nlm.nih.gov/31744826/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Secular trends in major osteoporotic fractures among 50+ adults in Denmark between 1995 and 2010

  https://pubmed.ncbi.nlm.nih.gov/31418061/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Time trends in oral bisphosphonate initiation in Ontario, Canada over 20 years reflect drug policy and healthcare delivery changes

  https://pubmed.ncbi.nlm.nih.gov/31317249/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Retraction Note to: Secular trends in major osteoporotic fractures among 50+ adults in Denmark between 1995 and 2010

  https://pubmed.ncbi.nlm.nih.gov/31286270/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Blood eosinophilia, use of inhaled corticosteroids, and risk of COPD exacerbations and mortality

  https://pubmed.ncbi.nlm.nih.gov/30264901/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Secular trends in major osteoporotic fractures among 50+ adults in Denmark between 1995 and 2010

  https://pubmed.ncbi.nlm.nih.gov/30151659/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

• Association between use of antidepressants or benzodiazepines and the risk of subsequent fracture among those aged 65+ in the Netherlands

  https://pubmed.ncbi.nlm.nih.gov/30112636/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1TuHRxU62XQx0jrP-lYrgZ_ZloBWlnW72-au_x_Hwb68-Ow9rk&fc=None&ff=20220713134318&v=2.17.7

STRENGTH AND WEAKNESSES AT WORK

- Year Of Promotion: 2018

- Areas Of Expertise: Ageing and Epidemiology

- Favorite statistical software: SAS

- Favorite research database: CPRD

- Favorite technique: Survival Analysis

- Best technical skill: Building SAS macros

- Best knowledge: Drug safety and effectiveness research

- Hated technique: Debugging SAS programs

- Research goal: Improving treatment success (and harm minimization) in patient populations underrepresented in clinical trials.

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PERSONAL STRENGTH AND WEAKNESSES

- Favorite dish: Cousa Mashi (Arabic dish), or almost all pasta

- Favorite place to live: Toronto

- Best sport skill: Equestrian

- Worst performance: Basketball

- Free time activity: Reading/Cooking

- Favorite quote: You miss 100% of the shots you do not take (Wayne Gretzky)