Biography

Björn Busse is currently head of a ‘Emmy Noether Research Group’ which is a 5 year-program run by the German Research Foundation (DFG). The group of Björn has recently been included in the DFG-Heisenberg Professorship program and is currently hosted by the Department of Osteology and Biomechanics at the University Medical Center Hamburg-Eppendorf.

He has a strong interest in skeletal imaging and bone quality analyses. In this context, Björn has graduated in bioengineering (2003), and has finished his Ph.D. at the Free and Humboldt University Berlin, Charité - University Medicine Berlin (2009), where he has focused on research regarding bone imaging and bone mineralization. In particular, he has developed skills in scanning (SEM) & backscattered electron microscopy, microanalysis, materials testing and bone histomorphometry.

Björn’s work provides a contribution to our understanding on the fracture of bone, specifically by focussing on aspects of bone quality, such as osseous changes with skeletal aging, osteoporosis, osteoporosis treatment strategies, osteomalacia, Paget’s disease of bone, from both a medical and engineering perspective.

He gained both an academic teaching and research experience while completing his post-doc research fellowship at the Lawrence Berkeley National Laboratory (LBNL) / Department of Materials Science and Engineering, at the University of California, Berkeley (2010-2011) funded through a stipend obtained from the German Research Foundation

List of 5 Best Publications

• The Role of GPR39 in Regulating Osteoblast Function, Bone Matrix Quality, and Gender-Specific Bone Homeostasis

  https://pubmed.ncbi.nlm.nih.gov/41041978/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Value of Spectral CT Techniques for the Assessment of Bone Marrow Infiltration in Multiple Myeloma: A Systematic Literature Review

  https://pubmed.ncbi.nlm.nih.gov/40701189/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• The role of burnout prevention in promoting healthy aging: frameworks for the Semmelweis Study and Semmelweis-EUniWell Workplace Health Promotion Program

  https://pubmed.ncbi.nlm.nih.gov/40627122/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Effects of K-wire diameter and insertion angle on femoral bone medial closing-wedge osteotomies: a finite element study

  https://pubmed.ncbi.nlm.nih.gov/40541981/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Characterization of Bone Matrix Mineralization and Osteocyte Lacunar Density Unveils Microstructural Impairment at the Main Femoral Fracture-Initiating Site in Type 2 Diabetes Mellitus

  https://pubmed.ncbi.nlm.nih.gov/40512394/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Improvements in hearing loss with bone-targeted enzyme replacement therapy are associated with corrected hypomineralization and osteocyte properties of auditory ossicles in Enpp1-deficient mice

  https://pubmed.ncbi.nlm.nih.gov/40495691/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Site-specific alterations of bone matrix mineralization, micro-hardness, and density of mineralized osteocyte lacunae in men with alcohol-associated liver disease: implications for vertebral fracture predilection

  https://pubmed.ncbi.nlm.nih.gov/40476716/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Intake of neutral core human milk oligosaccharides (HMOs) during early life improves long-term bone quality

  https://pubmed.ncbi.nlm.nih.gov/40403855/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Effects of different cortical all-suture anchor (Y-Knot RC) insertion points and deep vs. flat insertion on its biomechanical properties

  https://pubmed.ncbi.nlm.nih.gov/40398590/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• The role of purpose in life in healthy aging: implications for the Semmelweis Study and the Semmelweis-EUniWell Workplace Health Promotion Model Program

  https://pubmed.ncbi.nlm.nih.gov/40155585/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Hereditary pseudocholinesterase deficiency in a 4-year-old girl: a case report

  https://pubmed.ncbi.nlm.nih.gov/40148900/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Micro-gyms as a catalyst for healthy aging in university and healthcare settings: applications for the Semmelweis-EUniWell Workplace Health Promotion Model Program

  https://pubmed.ncbi.nlm.nih.gov/40088392/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Fracture characteristics of human cortical bone influenced by the duration of in vitro glycation

  https://pubmed.ncbi.nlm.nih.gov/39822214/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Bone quality analysis of the mandible in alcoholic liver cirrhosis: Anatomical, microstructural, and microhardness evaluation

  https://pubmed.ncbi.nlm.nih.gov/39708897/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Multi-scale inferomedial femoral neck bone quality in type 2 diabetes patients with fragility fracture

  https://pubmed.ncbi.nlm.nih.gov/39694129/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Bone-seeking tumor cells alter bone material quality parameters on the nanoscale in mice

  https://pubmed.ncbi.nlm.nih.gov/39486241/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Standardization of bone morphometry and mineral density assessments in zebrafish and other small laboratory fishes using X-ray radiography and micro-computed tomography

  https://pubmed.ncbi.nlm.nih.gov/39475005/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Sex-Specific Association Patterns of Bone Microstructure and Lower Leg Arterial Calcification

  https://pubmed.ncbi.nlm.nih.gov/39397150/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Eagle syndrome: tissue characteristics and structure of the styloid process

  https://pubmed.ncbi.nlm.nih.gov/39347481/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• High-fiber diet reduces bone formation but does not affect bone microarchitecture in type 2 diabetes individuals

  https://pubmed.ncbi.nlm.nih.gov/39253598/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• 2D vs. 3D Evaluation of Osteocyte Lacunae - Methodological Approaches, Recommended Parameters, and Challenges: A Narrative Review by the European Calcified Tissue Society (ECTS)

  https://pubmed.ncbi.nlm.nih.gov/38980532/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Lower microhardness along with less heterogeneous mineralization in the femoral neck of individuals with type 2 diabetes mellitus indicates higher fracture risk

  https://pubmed.ncbi.nlm.nih.gov/38741606/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Osteomodulin deficiency in mice causes a specific reduction of transversal cortical bone size

  https://pubmed.ncbi.nlm.nih.gov/38722812/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• A perspective on muscle phenotyping in musculoskeletal research

  https://pubmed.ncbi.nlm.nih.gov/38553405/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Alterations in compositional and cellular properties of the subchondral bone are linked to cartilage degeneration in hip osteoarthritis

  https://pubmed.ncbi.nlm.nih.gov/38403152/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• When Cortical Bone Matrix Properties Are Indiscernible between Elderly Men with and without Type 2 Diabetes, Fracture Resistance Follows Suit

  https://pubmed.ncbi.nlm.nih.gov/38130774/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Utility and Limitations of TALLYHO/JngJ as a Model for Type 2 Diabetes-Induced Bone Disease

  https://pubmed.ncbi.nlm.nih.gov/38130754/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Cortical microarchitecture and remodeling-associated gene expression related to oral cancer prognosis

  https://pubmed.ncbi.nlm.nih.gov/37970929/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Micropetrosis: Osteocyte Lacunar Mineralization in Aging and Disease

  https://pubmed.ncbi.nlm.nih.gov/37917286/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Perivascular invasion of primary human glioblastoma cells in organotypic human brain slices: human cells migrating in human brain

  https://pubmed.ncbi.nlm.nih.gov/37490233/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Corrigendum to "Impact of test environment on the fracture resistance of cortical bone" [J. Mech. Behav. Biomed. Mater. 129 (2022) 105155]

  https://pubmed.ncbi.nlm.nih.gov/37479625/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Why Animal Experiments Are Still Indispensable in Bone Research: A Statement by the European Calcified Tissue Society

  https://pubmed.ncbi.nlm.nih.gov/37314012/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Osteocyte apoptosis and cellular micropetrosis signify skeletal aging in type 1 diabetes

  https://pubmed.ncbi.nlm.nih.gov/36878337/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Zebrafish Tric-b is required for skeletal development and bone cells differentiation

  https://pubmed.ncbi.nlm.nih.gov/36755921/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Effects of Infantile Hypophosphatasia on Human Dental Tissue

  https://pubmed.ncbi.nlm.nih.gov/36414794/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome

  https://pubmed.ncbi.nlm.nih.gov/36346812/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• On the fracture behavior of cortical bone microstructure: The effects of morphology and material characteristics of bone structural components

  https://pubmed.ncbi.nlm.nih.gov/36334581/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Reduced Bone Mass and Increased Osteocyte Tartrate-Resistant Acid Phosphatase (TRAP) Activity, But Not Low Mineralized Matrix Around Osteocyte Lacunae, Are Restored After Recovery From Exogenous Hyperthyroidism in Male Mice

  https://pubmed.ncbi.nlm.nih.gov/36331133/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Human tibial cortical bone with high porosity in type 2 diabetes mellitus is accompanied by distinctive bone material properties

  https://pubmed.ncbi.nlm.nih.gov/36113843/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Dimorphic Mechanisms of Fragility in Diabetes Mellitus: the Role of Reduced Collagen Fibril Deformation

  https://pubmed.ncbi.nlm.nih.gov/36112316/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Antibacterial properties of functionalized silk fibroin and sericin membranes for wound healing applications in oral and maxillofacial surgery

  https://pubmed.ncbi.nlm.nih.gov/35929202/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Missense variant c.1460 T > C (p.L487P) enhances protein degradation of ER mannosyltransferase ALG9 in two new ALG9-CDG patients presenting with West syndrome and review of the literature

  https://pubmed.ncbi.nlm.nih.gov/35839600/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Keratinocyte-derived S100A9 modulates neutrophil infiltration and affects psoriasis-like skin and joint disease

  https://pubmed.ncbi.nlm.nih.gov/35788494/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Catalysis-Independent ENPP1 Protein Signaling Regulates Mammalian Bone Mass

  https://pubmed.ncbi.nlm.nih.gov/35773783/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• A finite element study on femoral locking compression plate design using genetic optimization method

  https://pubmed.ncbi.nlm.nih.gov/35500494/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Impact of test environment on the fracture resistance of cortical bone

  https://pubmed.ncbi.nlm.nih.gov/35313188/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Orthogonally-polarized excitation for improved two-photon and second-harmonic-generation microscopy, applied to neurotransmitter imaging with GPCR-based sensors

  https://pubmed.ncbi.nlm.nih.gov/35284188/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Spine Metastases in Immunocompromised Mice after Intracardiac Injection of MDA-MB-231-SCP2 Breast Cancer Cells

  https://pubmed.ncbi.nlm.nih.gov/35158823/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Bone fragility in diabetes: novel concepts and clinical implications

  https://pubmed.ncbi.nlm.nih.gov/35101185/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

• Selective Inner Hair Cell Loss in a Neonate Harbor Seal (Phoca vitulina)

  https://pubmed.ncbi.nlm.nih.gov/35049802/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20251017183224&v=2.18.0.post9+e462414

STRENGTH AND WEAKNESSES AT WORK

- Favorite Cell: Osteocyte

- Favorite Protein: Strontium

- Best technical skill: SEM

- Best knowledge: Bone quality

- Research goal: To improve diagnostics and treatment options for maintaining bone quality

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PERSONAL STRENGTH AND WEAKNESSES

- Favorite dish: Spaghetti aglio, olio e peperoncino

- Favorite place to live: in mediterranean climate

- Best sport skill: Football (Soccer)

- Worst performance: Card games

- Free time activity: Music/Concerts

- Favorite quote: What I enjoy most is doing something I’ve never done before (Karl Lagerfeld)