Biography

Björn Busse is currently head of a ‘Emmy Noether Research Group’ which is a 5 year-program run by the German Research Foundation (DFG). The group of Björn has recently been included in the DFG-Heisenberg Professorship program and is currently hosted by the Department of Osteology and Biomechanics at the University Medical Center Hamburg-Eppendorf.

He has a strong interest in skeletal imaging and bone quality analyses. In this context, Björn has graduated in bioengineering (2003), and has finished his Ph.D. at the Free and Humboldt University Berlin, Charité - University Medicine Berlin (2009), where he has focused on research regarding bone imaging and bone mineralization. In particular, he has developed skills in scanning (SEM) & backscattered electron microscopy, microanalysis, materials testing and bone histomorphometry.

Björn’s work provides a contribution to our understanding on the fracture of bone, specifically by focussing on aspects of bone quality, such as osseous changes with skeletal aging, osteoporosis, osteoporosis treatment strategies, osteomalacia, Paget’s disease of bone, from both a medical and engineering perspective.

He gained both an academic teaching and research experience while completing his post-doc research fellowship at the Lawrence Berkeley National Laboratory (LBNL) / Department of Materials Science and Engineering, at the University of California, Berkeley (2010-2011) funded through a stipend obtained from the German Research Foundation

List of 5 Best Publications

• Perivascular invasion of primary human glioblastoma cells in organotypic human brain slices: human cells migrating in human brain

  https://pubmed.ncbi.nlm.nih.gov/37490233/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Corrigendum to "Impact of test environment on the fracture resistance of cortical bone" [J. Mech. Behav. Biomed. Mater. 129 (2022) 105155]

  https://pubmed.ncbi.nlm.nih.gov/37479625/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Why Animal Experiments Are Still Indispensable in Bone Research: A Statement by the European Calcified Tissue Society

  https://pubmed.ncbi.nlm.nih.gov/37314012/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Osteocyte apoptosis and cellular micropetrosis signify skeletal aging in type 1 diabetes

  https://pubmed.ncbi.nlm.nih.gov/36878337/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Zebrafish Tric-b is required for skeletal development and bone cells differentiation

  https://pubmed.ncbi.nlm.nih.gov/36755921/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Effects of Infantile Hypophosphatasia on Human Dental Tissue

  https://pubmed.ncbi.nlm.nih.gov/36414794/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome

  https://pubmed.ncbi.nlm.nih.gov/36346812/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• On the fracture behavior of cortical bone microstructure: The effects of morphology and material characteristics of bone structural components

  https://pubmed.ncbi.nlm.nih.gov/36334581/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Reduced Bone Mass and Increased Osteocyte Tartrate-Resistant Acid Phosphatase (TRAP) Activity, But Not Low Mineralized Matrix Around Osteocyte Lacunae, Are Restored After Recovery From Exogenous Hyperthyroidism in Male Mice

  https://pubmed.ncbi.nlm.nih.gov/36331133/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Human tibial cortical bone with high porosity in type 2 diabetes mellitus is accompanied by distinctive bone material properties

  https://pubmed.ncbi.nlm.nih.gov/36113843/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Dimorphic Mechanisms of Fragility in Diabetes Mellitus: the Role of Reduced Collagen Fibril Deformation

  https://pubmed.ncbi.nlm.nih.gov/36112316/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Antibacterial properties of functionalized silk fibroin and sericin membranes for wound healing applications in oral and maxillofacial surgery

  https://pubmed.ncbi.nlm.nih.gov/35929202/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Missense variant c.1460 T > C (p.L487P) enhances protein degradation of ER mannosyltransferase ALG9 in two new ALG9-CDG patients presenting with West syndrome and review of the literature

  https://pubmed.ncbi.nlm.nih.gov/35839600/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Keratinocyte-derived S100A9 modulates neutrophil infiltration and affects psoriasis-like skin and joint disease

  https://pubmed.ncbi.nlm.nih.gov/35788494/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Catalysis-Independent ENPP1 Protein Signaling Regulates Mammalian Bone Mass

  https://pubmed.ncbi.nlm.nih.gov/35773783/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• A finite element study on femoral locking compression plate design using genetic optimization method

  https://pubmed.ncbi.nlm.nih.gov/35500494/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Impact of test environment on the fracture resistance of cortical bone

  https://pubmed.ncbi.nlm.nih.gov/35313188/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Orthogonally-polarized excitation for improved two-photon and second-harmonic-generation microscopy, applied to neurotransmitter imaging with GPCR-based sensors

  https://pubmed.ncbi.nlm.nih.gov/35284188/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Spine Metastases in Immunocompromised Mice after Intracardiac Injection of MDA-MB-231-SCP2 Breast Cancer Cells

  https://pubmed.ncbi.nlm.nih.gov/35158823/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Bone fragility in diabetes: novel concepts and clinical implications

  https://pubmed.ncbi.nlm.nih.gov/35101185/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Selective Inner Hair Cell Loss in a Neonate Harbor Seal (Phoca vitulina)

  https://pubmed.ncbi.nlm.nih.gov/35049802/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Impaired bone quality in the superolateral femoral neck occurs independent of hip geometry and bone mineral density

  https://pubmed.ncbi.nlm.nih.gov/34999261/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Perspective of the GEMSTONE Consortium on Current and Future Approaches to Functional Validation for Skeletal Genetic Disease Using Cellular, Molecular and Animal-Modeling Techniques

  https://pubmed.ncbi.nlm.nih.gov/34938269/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Influence of X-rays and gamma-rays on the mechanical performance of human bone factoring out intraindividual bone structure and composition indices

  https://pubmed.ncbi.nlm.nih.gov/34927043/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Bone Phenotyping Approaches in Human, Mice and Zebrafish - Expert Overview of the EU Cost Action GEMSTONE ("GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork")

  https://pubmed.ncbi.nlm.nih.gov/34925226/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Decreased Trabecular Bone Mass in Col22a1-Deficient Mice

  https://pubmed.ncbi.nlm.nih.gov/34831244/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• The WNT1^G177C mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV

  https://pubmed.ncbi.nlm.nih.gov/34759273/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Bone loss recovery in mice following microgravity with concurrent bone-compartment-specific osteocyte characteristics

  https://pubmed.ncbi.nlm.nih.gov/34642917/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Loss of glucocorticoid rhythm induces an osteoporotic phenotype in female mice

  https://pubmed.ncbi.nlm.nih.gov/34592793/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Reorganization of the osteocyte lacuno-canalicular network characteristics in tumor sites of an immunocompetent murine model of osteotropic cancers

  https://pubmed.ncbi.nlm.nih.gov/34174502/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Variability in stem taper surface topography affects the degree of corrosion and fretting in total hip arthroplasty

  https://pubmed.ncbi.nlm.nih.gov/33931680/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Bone quality analysis of jaw bones in individuals with type 2 diabetes mellitus-post mortem anatomical and microstructural evaluation

  https://pubmed.ncbi.nlm.nih.gov/33694028/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• NIH Funding for Surgeon-Scientists in the US: What Is the Current Status?

  https://pubmed.ncbi.nlm.nih.gov/33588041/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Topographical mapping of the mechanical characteristics of the human neurocranium considering the role of individual layers

  https://pubmed.ncbi.nlm.nih.gov/33580114/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Skeletal Biology and Disease Modeling in Zebrafish

  https://pubmed.ncbi.nlm.nih.gov/33484578/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Temporomandibular Joint Osteoarthritis: Regenerative Treatment by a Stem Cell Containing Advanced Therapy Medicinal Product (ATMP)-An In Vivo Animal Trial

  https://pubmed.ncbi.nlm.nih.gov/33466246/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Response of the ENPP1-Deficient Skeletal Phenotype to Oral Phosphate Supplementation and/or Enzyme Replacement Therapy: Comparative Studies in Humans and Mice

  https://pubmed.ncbi.nlm.nih.gov/33465815/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Collagen Fiber Orientation Is Coupled with Specific Nano-Compositional Patterns in Dark and Bright Osteons Modulating Their Biomechanical Properties

  https://pubmed.ncbi.nlm.nih.gov/33404232/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Breaking new ground in mineralized tissue: Assessing tissue quality in clinical and laboratory studies

  https://pubmed.ncbi.nlm.nih.gov/33157423/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• High-Throughput Lossy-to-Lossless 3D Image Compression

  https://pubmed.ncbi.nlm.nih.gov/33095708/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Warmth Prevents Bone Loss Through the Gut Microbiota

  https://pubmed.ncbi.nlm.nih.gov/32916104/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• More Bone with Less Minerals? The Effects of Dietary Phosphorus on the Post-Cranial Skeleton in Zebrafish

  https://pubmed.ncbi.nlm.nih.gov/32751494/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Individuals with type 2 diabetes mellitus show dimorphic and heterogeneous patterns of loss in femoral bone quality

  https://pubmed.ncbi.nlm.nih.gov/32730921/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• A Clinical Perspective on Advanced Developments in Bone Biopsy Assessment in Rare Bone Disorders

  https://pubmed.ncbi.nlm.nih.gov/32714279/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Elevated Bone Hardness Under Denosumab Treatment, With Persisting Lower Osteocyte Viability During Discontinuation

  https://pubmed.ncbi.nlm.nih.gov/32499755/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Disruption of the hepcidin/ferroportin regulatory circuitry causes low axial bone mass in mice

  https://pubmed.ncbi.nlm.nih.gov/32380257/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Fgfr3 Is a Positive Regulator of Osteoblast Expansion and Differentiation During Zebrafish Skull Vault Development

  https://pubmed.ncbi.nlm.nih.gov/32379366/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Crtap and p3h1 knock out zebrafish support defective collagen chaperoning as the cause of their osteogenesis imperfecta phenotype

  https://pubmed.ncbi.nlm.nih.gov/32173581/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Phenomenon of osteocyte lacunar mineralization: indicator of former osteocyte death and a novel marker of impaired bone quality?

  https://pubmed.ncbi.nlm.nih.gov/32168472/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

• Multimodal X-ray imaging of nanocontainer-treated macrophages and calcium distribution in the perilacunar bone matrix

  https://pubmed.ncbi.nlm.nih.gov/32019946/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1T_hRitDi643TN0mJ_TeNB5gs1Y8QtCzC7rj-JM_SHNyHPuQY6&fc=None&ff=20230922215922&v=2.17.9.post6+86293ac

STRENGTH AND WEAKNESSES AT WORK

- Favorite Cell: Osteocyte

- Favorite Protein: Strontium

- Best technical skill: SEM

- Best knowledge: Bone quality

- Research goal: To improve diagnostics and treatment options for maintaining bone quality

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PERSONAL STRENGTH AND WEAKNESSES

- Favorite dish: Spaghetti aglio, olio e peperoncino

- Favorite place to live: in mediterranean climate

- Best sport skill: Football (Soccer)

- Worst performance: Card games

- Free time activity: Music/Concerts

- Favorite quote: What I enjoy most is doing something I’ve never done before (Karl Lagerfeld)