Academic Title: PhD
First Name: Ciro
Last Name: Menale
Academic Degree: Biotechnology
Member Since: May 2018
Institution: Department of Clinical Medicine and Surgery, University of Naples "Federico II"
Ciro Menale graduated in Molecular and Industrial Biotechnology at University of Naples “Federico II” in 2010, working in the field of Enzyme Biotechnology. Ciro received his PhD in Biomedical and Biotechnological Science – “Food and Health” at University of Campania “Luigi Vanvitelli” in 2013, in Naples, Italy. During his PhD he was focused on gene expression regulation of the adipose tissue in pathological conditions, and he deepened his studies in murine models at YALE University School of Medicine, working on hypothalamic regulation of glucose homeostasis and whole body energy balance. In that context he started to be familiar also with immunology. In parallel he was interested in nanotechnology for cancer treatment.
As a PostDoc he moved to the bone field. His research was mainly focused on bone marrow mesenchymal stromal cells (MSC) and iPSC-derived MSC Transplantation by exploiting 3D culture models as novel approach for RANKL-dependent Osteopetrosis. At the same time, taking advantage of the osteopetrotic Rankl-/- mouse model, he contributed to investigate a novel anabolic role of RANKL in bone. Ciro also investigated the interaction of bone and immune cells focusing on bone loss and immune system defects driven by oxidative stress in bone cells. Today he is RTD at University of Naples "Federico II", Italy, working on bone cell metabolism, glucose and energy balance
List of 5 Best Publications
- Absence of Dipeptidyl Peptidase 3 increases oxidative stress and causes bone losshttps://www.ncbi.nlm.nih.gov/pubmed/31295380
- 3D Bone Biomimetic Scaffolds for Basic and Translational Studies with Mesenchymal Stem Cells. https://www.ncbi.nlm.nih.gov/pubmed/30322134
- Mesenchymal Stromal Cell-Seeded Biomimetic Scaffolds as a Factory of Soluble RANKL in Rankl-Deficient Osteopetrosis.https://www.ncbi.nlm.nih.gov/pubmed/30184340
- Soluble Factors on Stage to Direct Mesenchymal Stem Cells Fate.https://www.ncbi.nlm.nih.gov/pubmed/28567372
- Murine Rankl-/- Mesenchymal Stromal Cells Display an Osteogenic Differentiation Defect Improved by a RANKL-Expressing Lentiviral Vector.https://www.ncbi.nlm.nih.gov/pubmed/28100034