Biography

Education and training 2000: MD in Medicine at the University of Siena, Siena, Italy 2005: Post-graduate specialization in Internal Medicine at the University of Siena, Siena, Italy 2012: PhD in Biomedicine and Immunological Sciences - Osteometabolic Area at the University of Siena, Siena, Italy

Professional Experience and Research Activities

–1997-2000: Internal student at the Institute of Internal Medicine of the University of Siena (inpatient and outpatient care in Internal Medicine) - 2000-2005: Fellow at the Department of Internal Medicine Endocrine-Metabolic Sciences and Biochemistry of the University of Siena. Served as physician (inpatient and outpatient care in Internal Medicine), participated in training medical students and conducted research activities in internal Medicine, bone metabolism and molecular biology (Genetics of Osteoporosis and Paget's disease of bone)- 2005-2009: post-graduate fellowship at the Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry,University of Siena (Clinical, teaching and research activity) in Internal Medicine (MED09). -2009-2012: PhD fellowship University of Siena -2013: post-doc fellowship at the Department of Medicine Surgery and Neurosciences University of Siena -2014-to date: post-graduate fellowship at Age Related Diseseas Unit, Fondazione Centro San Raffaele, Milan, Italy and Department of Medicine Surgery and Neurosciences, Unversity of Siena, Italy

She participated as co-investigator at different research projects on the genetics of different skeletal disorders including osteoporosis and Paget's disease of bone. Due to her recognized expertise in this field she has been invited as speaker at national and international meetings and she has been author of several articles and editorials in major peer-reviewed journals

List of 5 Best Publications

• Vitamin D Deficiency in COVID-19 Patients and Role of Calcifediol Supplementation

  https://pubmed.ncbi.nlm.nih.gov/37571329/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Vitamin D Deficiency and Cardiovascular Mortality: Retrospective Analysis "Siena Osteoporosis" Cohort

  https://pubmed.ncbi.nlm.nih.gov/37571241/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Dietary Vitamin D Intake in Italian Subjects: Validation of a Frequency Food Questionnaire (FFQ)

  https://pubmed.ncbi.nlm.nih.gov/37447294/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Role of Advanced Glycation End-Products and Oxidative Stress in Type-2-Diabetes-Induced Bone Fragility and Implications on Fracture Risk Stratification

  https://pubmed.ncbi.nlm.nih.gov/37107303/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Drug treatment strategies for paget's disease: relieving pain and preventing progression

  https://pubmed.ncbi.nlm.nih.gov/36961938/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Validation of the clinical consensus recommendations on the management of fracture risk in postmenopausal women with type 2 diabetes

  https://pubmed.ncbi.nlm.nih.gov/36404237/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Update on the pathogenesis and genetics of Paget's disease of bone

  https://pubmed.ncbi.nlm.nih.gov/36035996/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• The effects of vegetarian diets on bone health: A literature review

  https://pubmed.ncbi.nlm.nih.gov/35992115/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Bone Fragility in Gastrointestinal Disorders

  https://pubmed.ncbi.nlm.nih.gov/35269854/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes

  https://pubmed.ncbi.nlm.nih.gov/35004568/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Vitamin D and COVID-19 severity and related mortality: a prospective study in Italy

  https://pubmed.ncbi.nlm.nih.gov/34126960/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Management of bone fragility in type 2 diabetes: Perspective from an interdisciplinary expert panel

  https://pubmed.ncbi.nlm.nih.gov/34059385/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Effects of Bisphosphonate Treatment on Circulating Lipid and Glucose Levels in Patients with Metabolic Bone Disorders

  https://pubmed.ncbi.nlm.nih.gov/33559705/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Energy Metabolism and Ketogenic Diets: What about the Skeletal Health? A Narrative Review and a Prospective Vision for Planning Clinical Trials on this Issue

  https://pubmed.ncbi.nlm.nih.gov/33406758/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Increased Prevalence of Nephrolithiasis and Hyperoxaluria in Paget Disease of Bone

  https://pubmed.ncbi.nlm.nih.gov/32827434/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Infection by CagA-Positive Helicobacter pylori Strains and Bone Fragility: A Prospective Cohort Study

  https://pubmed.ncbi.nlm.nih.gov/32790186/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Updates in epidemiology, pathophysiology and management strategies of glucocorticoid-induced osteoporosis

  https://pubmed.ncbi.nlm.nih.gov/32584619/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Pathophysiology and Management of Type 2 Diabetes Mellitus Bone Fragility

  https://pubmed.ncbi.nlm.nih.gov/32566682/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Mutation of PFN1 Gene in an Early Onset, Polyostotic Paget-like Disease

  https://pubmed.ncbi.nlm.nih.gov/32392277/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Emerging therapeutic targets for osteoporosis

  https://pubmed.ncbi.nlm.nih.gov/32050822/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Treatment options for glucocorticoid-induced osteoporosis

  https://pubmed.ncbi.nlm.nih.gov/32004105/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Prediction of hypertension, diabetes and fractures in eucortisolemic women by measuring parameters of cortisol milieu

  https://pubmed.ncbi.nlm.nih.gov/31989409/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Preventive Role of Vitamin D Supplementation for Acute Phase Reaction after Bisphosphonate Infusion in Paget's Disease

  https://pubmed.ncbi.nlm.nih.gov/31634910/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Vitamin D Status in Paget Disease of Bone and Efficacy-Safety Profile of Cholecalciferol Treatment in Pagetic Patients with Hypovitaminosis D

  https://pubmed.ncbi.nlm.nih.gov/31236621/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Cortisol Secretion, Sensitivity, and Activity Are Associated With Hypertension in Postmenopausal Eucortisolemic Women

  https://pubmed.ncbi.nlm.nih.gov/31112276/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Efficacy and safety of abaloparatide for the treatment of post-menopausal osteoporosis

  https://pubmed.ncbi.nlm.nih.gov/30856013/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Paget's Disease of Bone

  https://pubmed.ncbi.nlm.nih.gov/30671590/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Recent advances in models for screening potential osteoporosis drugs

  https://pubmed.ncbi.nlm.nih.gov/29869573/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• The Potential Role of miRNAs as New Biomarkers for Osteoporosis

  https://pubmed.ncbi.nlm.nih.gov/29853878/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Interleukin-6 trans-signaling and pathological low back pain in patients with Paget disease of bone

  https://pubmed.ncbi.nlm.nih.gov/29697533/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• MicroRNAs in bone diseases

  https://pubmed.ncbi.nlm.nih.gov/27904930/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Treatment needs and current options for postmenopausal osteoporosis

  https://pubmed.ncbi.nlm.nih.gov/27055223/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• ZNF687 Mutations in Severe Paget Disease of Bone Associated with Giant Cell Tumor

  https://pubmed.ncbi.nlm.nih.gov/26849110/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Appropriate models for novel osteoporosis drug discovery and future perspectives

  https://pubmed.ncbi.nlm.nih.gov/26292627/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Hypovitaminosis D and organ damage in patients with arterial hypertension: a multicenter double blind randomised controlled trial of cholecalciferol supplementation (HYPODD) : study design, clinical procedures and treatment protocol

  https://pubmed.ncbi.nlm.nih.gov/25771895/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Clinical characteristics and evolution of giant cell tumor occurring in Paget's disease of bone

  https://pubmed.ncbi.nlm.nih.gov/25196811/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function

  https://pubmed.ncbi.nlm.nih.gov/24642144/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Beyond glycemic control in diabetes mellitus: effects of incretin-based therapies on bone metabolism

  https://pubmed.ncbi.nlm.nih.gov/23785355/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Endocrine actions of osteocalcin

  https://pubmed.ncbi.nlm.nih.gov/23737779/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Common susceptibility alleles and SQSTM1 mutations predict disease extent and severity in a multinational study of patients with Paget's disease

  https://pubmed.ncbi.nlm.nih.gov/23658060/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Giant cell tumor occurring in familial Paget's disease of bone: report of clinical characteristics and linkage analysis of a large pedigree

  https://pubmed.ncbi.nlm.nih.gov/22936311/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Lasofoxifene, from the preclinical drug discovery to the treatment of postmenopausal osteoporosis

  https://pubmed.ncbi.nlm.nih.gov/22647137/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Circulating sclerostin levels and bone turnover in type 1 and type 2 diabetes

  https://pubmed.ncbi.nlm.nih.gov/22399511/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Pharmacokinetic evaluation of toremifene and its clinical implications for the treatment of osteoporosis

  https://pubmed.ncbi.nlm.nih.gov/22356442/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Vitamin D deficiency and primary hyperparathyroidism

  https://pubmed.ncbi.nlm.nih.gov/21985980/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• A nonsynonymous TNFRSF11A variation increases NFκB activity and the severity of Paget's disease

  https://pubmed.ncbi.nlm.nih.gov/21987421/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• The association of body composition and sex hormones with quantitative ultrasound parameters at the calcaneus and phalanxes in elderly women

  https://pubmed.ncbi.nlm.nih.gov/21986718/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Aromatase activity and bone loss

  https://pubmed.ncbi.nlm.nih.gov/21874760/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Aromatase activity and bone loss in men

  https://pubmed.ncbi.nlm.nih.gov/21772971/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

• Bone fragility in men: where are we?

  https://pubmed.ncbi.nlm.nih.gov/20938224/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1z_pxc-9fhPQGO3g0xWkB3znyMcMavLzLJHrpafo95-UGJegWt&fc=None&ff=20230922122249&v=2.17.9.post6+86293ac

STRENGTH AND WEAKNESSES AT WORK

- Favorite Cell: Osteoclast

- Favorite Protein: p62/sequestosome

- Best technical skill: Clinical management of patients

- Best knowledge: Paget's disease of bone, osteoporosis, metabolic bone disorders

- Hated technique: hystomorphometry

- Research goal: Improve the knowledge of the pathogeneis of metabolic bone disorders to better manage patients

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PERSONAL STRENGTH AND WEAKNESSES

- Favorite dish: Fish

- Favorite place to live: Italy

- Best sport skill: Tennis

- Worst performance: Football

- Free time activity: Travelling, Reading

- Favorite quote: Science is a beautiful gift to humanity; we should not distort it (A.P.J. Abdul Kalam)