Biography

Graziana Colaianni received her PhD in Science and Cellular Technologies from the University of Bari (Italy) in 2005.
During her post-doc, she was involved in analyzing the effects of hypothalamic and steroids hormones by studying the bone phenotype of mice genetically modified for the oxytocin receptor, vasopressin receptor and double knock out for both receptors. Some of these studies have been carried out at the Mount Sinai School of Medicine (New York, USA), where she has been working as post-doctoral fellow.
She has also been involved in two projects supported by National Aeronautics and Space Administration (NASA), European and Italian Space Agency (ESA and ASI) for studying the effect of microgravity on bone tissue, during the Space flight missions Columbia STS-107, FOTON-M3 and Dragon SpaceX CRS-14. These projects generated her major interest in the field of osteoporosis and muscle atrophy related to microgravity and mechanical loading.
Currently, she is mainly working on bone-muscle interaction. Her recent works showed that the miokine Irisin, secreted by skeletal muscle during physical activity, plays a central role in bone metabolism, driving positive effects on bone mineral density and cortical bone geometry.

List of invited presentations

• 27/05/2018Sunday, May 27. h 09:40 - 09:50 Auditorium 1 Plenary Oral Presentations 1: Bone regulators Link: http://www.ects2018.org/programme/

List of 5 Best Publications

• Irisin Prevents the Effects of Simulated Microgravity on Bone and Muscle Differentiation Markers

  https://pubmed.ncbi.nlm.nih.gov/40654332/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Correlation Between Irisin and Cognitive Functions in Alzheimer Dementia

  https://pubmed.ncbi.nlm.nih.gov/40560607/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Influence of Non-Cross-Linking AGEs on Mechanical Properties and Morphological Features of Tropocollagen Peptides: A Molecular Dynamics Study

  https://pubmed.ncbi.nlm.nih.gov/40343761/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Irisin and Metastatic Melanoma: Selective Anti-Invasiveness Activity in BRAF Wild-Type Cells

  https://pubmed.ncbi.nlm.nih.gov/39859367/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Editorial: Metabolic disorders as risk factors for osteoarthritis and targeted therapies for this pathology

  https://pubmed.ncbi.nlm.nih.gov/39835262/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Irisin Treatment Prevents Isoproterenol-Induced Cardiac Fibrosis in Mice

  https://pubmed.ncbi.nlm.nih.gov/39600275/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Multiscale and multidisciplinary analysis of aging processes in bone

  https://pubmed.ncbi.nlm.nih.gov/38879533/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Irisin prevents trabecular bone damage and tumor invasion in a mouse model of multiple myeloma

  https://pubmed.ncbi.nlm.nih.gov/38855797/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Irisin Levels in Cerebrospinal Fluid Correlate with Biomarkers and Clinical Dementia Scores in Alzheimer Disease

  https://pubmed.ncbi.nlm.nih.gov/38780366/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• LIGHT/TNFSF14 Affects Adipose Tissue Phenotype

  https://pubmed.ncbi.nlm.nih.gov/38255789/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Irisin Protects against Loss of Trabecular Bone Mass and Strength in Adult Ovariectomized Mice by Stimulating Osteoblast Activity

  https://pubmed.ncbi.nlm.nih.gov/37373043/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Short-Term Irisin Treatment Enhanced Neurotrophin Expression Differently in the Hippocampus and the Prefrontal Cortex of Young Mice

  https://pubmed.ncbi.nlm.nih.gov/37298063/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Once-Daily Subcutaneous Irisin Administration Mitigates Depression- and Anxiety-like Behavior in Young Mice

  https://pubmed.ncbi.nlm.nih.gov/37047687/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Irisin Role in Chondrocyte 3D Culture Differentiation and Its Possible Applications

  https://pubmed.ncbi.nlm.nih.gov/36839906/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Vitamin D Increases Irisin Serum Levels and the Expression of Its Precursor in Skeletal Muscle

  https://pubmed.ncbi.nlm.nih.gov/36835539/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Elevated Expression of ADAM10 in Skeletal Muscle of Patients with Idiopathic Inflammatory Myopathies Could Be Responsible for FNDC5/Irisin Unbalance

  https://pubmed.ncbi.nlm.nih.gov/36768791/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Irisin Modulates Inflammatory, Angiogenic, and Osteogenic Factors during Fracture Healing

  https://pubmed.ncbi.nlm.nih.gov/36768133/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Time-dependent unloading effects on muscle and bone and involvement of FNDC5/irisin axis

  https://pubmed.ncbi.nlm.nih.gov/36658231/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Impact of 10-day bed rest on serum levels of irisin and markers of musculoskeletal metabolism

  https://pubmed.ncbi.nlm.nih.gov/36475382/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Antidepressant Effect of Intermittent Long-Term Systemic Administration of Irisin in Mice

  https://pubmed.ncbi.nlm.nih.gov/35886944/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Irisin Serum Levels and Skeletal Muscle Assessment in a Cohort of Charcot-Marie-Tooth Patients

  https://pubmed.ncbi.nlm.nih.gov/35634506/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Irisin and Secondary Osteoporosis in Humans

  https://pubmed.ncbi.nlm.nih.gov/35054874/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Systemic Administration of Recombinant Irisin Accelerates Fracture Healing in Mice

  https://pubmed.ncbi.nlm.nih.gov/34639200/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• The Novel Role of PGC1α in Bone Metabolism

  https://pubmed.ncbi.nlm.nih.gov/33925111/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• The Myokine Irisin Promotes Osteogenic Differentiation of Dental Bud-Derived MSCs

  https://pubmed.ncbi.nlm.nih.gov/33916859/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• In Reply to the Letter to the Editor: Involvement of Irisin in Age-Related Osteoporosis and Its Inhibitory Effect on the Senescent Marker p21 in Osteoblasts

  https://pubmed.ncbi.nlm.nih.gov/33600620/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Corrigendum to: The role of hyperhomocysteinemia as well as folate, vitamin B6 and B12 deficiencies in osteoporosis - a systematic review

  https://pubmed.ncbi.nlm.nih.gov/33554504/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• The effect of Irisin on bone cells in vivo and in vitro

  https://pubmed.ncbi.nlm.nih.gov/33449117/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts

  https://pubmed.ncbi.nlm.nih.gov/33053231/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Irisin prevents microgravity-induced impairment of osteoblast differentiation in vitro during the space flight CRS-14 mission

  https://pubmed.ncbi.nlm.nih.gov/32539174/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Myokines and Osteokines in the Pathogenesis of Muscle and Bone Diseases

  https://pubmed.ncbi.nlm.nih.gov/32514668/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Pregnancy and lactation, a challenge for the skeleton

  https://pubmed.ncbi.nlm.nih.gov/32438342/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• LIGHT/TNFSF14 regulates estrogen deficiency-induced bone loss

  https://pubmed.ncbi.nlm.nih.gov/31990039/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Irisin promotes growth, migration and matrix formation in human periodontal ligament cells

  https://pubmed.ncbi.nlm.nih.gov/31869727/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Oxytocin regulates body composition

  https://pubmed.ncbi.nlm.nih.gov/31843930/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Irisin Prevents Disuse-Induced Osteocyte Apoptosis

  https://pubmed.ncbi.nlm.nih.gov/31826311/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• LIGHT/TNFSF14 Promotes Osteolytic Bone Metastases in Non-small Cell Lung Cancer Patients

  https://pubmed.ncbi.nlm.nih.gov/31826304/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Effects of Sweet Cherry Polyphenols on Enhanced Osteoclastogenesis Associated With Childhood Obesity

  https://pubmed.ncbi.nlm.nih.gov/31130968/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Mechanisms Involved in Childhood Obesity-Related Bone Fragility

  https://pubmed.ncbi.nlm.nih.gov/31130918/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Irisin and Bone: From Preclinical Studies to the Evaluation of Its Circulating Levels in Different Populations of Human Subjects

  https://pubmed.ncbi.nlm.nih.gov/31091695/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Stemness genes expression in naïve vs. osteodifferentiated human dental-derived stem cells

  https://pubmed.ncbi.nlm.nih.gov/31002142/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• A Novel Interplay Between Irisin and PTH: From Basic Studies to Clinical Evidence in Hyperparathyroidism

  https://pubmed.ncbi.nlm.nih.gov/30759249/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Irisin serum levels are positively correlated with bone mineral status in a population of healthy children

  https://pubmed.ncbi.nlm.nih.gov/30683930/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• LIGHT/TNFSF14 as a New Biomarker of Bone Disease in Multiple Myeloma Patients Experiencing Therapeutic Regimens

  https://pubmed.ncbi.nlm.nih.gov/30405638/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Erratum to "Vitamin D Promotes MSC Osteogenic Differentiation Stimulating Cell Adhesion and αVβ3 Expression"

  https://pubmed.ncbi.nlm.nih.gov/30363736/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• An update on the role of RANKL-RANK/osteoprotegerin and WNT-ß-catenin signaling pathways in pediatric diseases

  https://pubmed.ncbi.nlm.nih.gov/30343446/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Deletion of the Transcription Factor PGC-1α in Mice Negatively Regulates Bone Mass

  https://pubmed.ncbi.nlm.nih.gov/30094757/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Irisin Serum Levels in Metabolic Syndrome Patients Treated with Three Different Diets: A Post-Hoc Analysis from a Randomized Controlled Clinical Trial

  https://pubmed.ncbi.nlm.nih.gov/29958455/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• Vitamin D Promotes MSC Osteogenic Differentiation Stimulating Cell Adhesion and αVβ3 Expression

  https://pubmed.ncbi.nlm.nih.gov/29681950/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

• High irisin levels are associated with better glycemic control and bone health in children with Type 1 diabetes

  https://pubmed.ncbi.nlm.nih.gov/29679630/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20251102184622&v=2.18.0.post22+67771e2

STRENGTH AND WEAKNESSES AT WORK

- Areas Of Expertise: Ageing, Bone Density, Endocrinology, Molecular Biology, Muscle, Nutrition, Osteoporosis, Physical Activity, and Energy Metabolism

- Favorite Cell: Osteoblast

- Favorite Protein: Osteocalcin

- Best technical skill: microCT

- Best knowledge: Bone and Muscle talk

- Hated technique: FACS

- Research goal: Fight against osteoporosis and muscular atrophy in bedridden/paralytic patients and in astronauts during space flight missions.

Back to members

PERSONAL STRENGTH AND WEAKNESSES

- Favorite dish: Risotto

- Favorite place to live: Oslo (Norway)

- Best sport skill: Ski

- Worst performance: To sing

- Free time activity: Travel

- Favorite quote: I have not failed. I've just found 10,000 ways that won't work.(T. A. Edison)