Biography
Graziana Colaianni received her PhD in Science and Cellular Technologies from the University of Bari (Italy) in 2005.
During her post-doc, she was involved in analyzing the effects of hypothalamic and steroids hormones by studying the bone phenotype of mice genetically modified for the oxytocin receptor, vasopressin receptor and double knock out for both receptors. Some of these studies have been carried out at the Mount Sinai School of Medicine (New York, USA), where she has been working as post-doctoral fellow.
She has also been involved in two projects supported by National Aeronautics and Space Administration (NASA), European and Italian Space Agency (ESA and ASI) for studying the effect of microgravity on bone tissue, during the Space flight missions Columbia STS-107, FOTON-M3 and Dragon SpaceX CRS-14. These projects generated her major interest in the field of osteoporosis and muscle atrophy related to microgravity and mechanical loading.
Currently, she is mainly working on bone-muscle interaction. Her recent works showed that the miokine Irisin, secreted by skeletal muscle during physical activity, plays a central role in bone metabolism, driving positive effects on bone mineral density and cortical bone geometry.
List of invited presentations
- 27/05/2018Sunday, May 27. h 09:40 - 09:50 Auditorium 1 Plenary Oral Presentations 1: Bone regulators Link: http://www.ects2018.org/programme/
List of 5 Best Publications
Irisin Protects against Loss of Trabecular Bone Mass and Strength in Adult Ovariectomized Mice by Stimulating Osteoblast Activity
https://pubmed.ncbi.nlm.nih.gov/37373043/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acShort-Term Irisin Treatment Enhanced Neurotrophin Expression Differently in the Hippocampus and the Prefrontal Cortex of Young Mice
https://pubmed.ncbi.nlm.nih.gov/37298063/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acOnce-Daily Subcutaneous Irisin Administration Mitigates Depression- and Anxiety-like Behavior in Young Mice
https://pubmed.ncbi.nlm.nih.gov/37047687/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acIrisin Role in Chondrocyte 3D Culture Differentiation and Its Possible Applications
https://pubmed.ncbi.nlm.nih.gov/36839906/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acVitamin D Increases Irisin Serum Levels and the Expression of Its Precursor in Skeletal Muscle
https://pubmed.ncbi.nlm.nih.gov/36835539/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acElevated Expression of ADAM10 in Skeletal Muscle of Patients with Idiopathic Inflammatory Myopathies Could Be Responsible for FNDC5/Irisin Unbalance
https://pubmed.ncbi.nlm.nih.gov/36768791/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acIrisin Modulates Inflammatory, Angiogenic, and Osteogenic Factors during Fracture Healing
https://pubmed.ncbi.nlm.nih.gov/36768133/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acTime-dependent unloading effects on muscle and bone and involvement of FNDC5/irisin axis
https://pubmed.ncbi.nlm.nih.gov/36658231/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acImpact of 10-day bed rest on serum levels of irisin and markers of musculoskeletal metabolism
https://pubmed.ncbi.nlm.nih.gov/36475382/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acAntidepressant Effect of Intermittent Long-Term Systemic Administration of Irisin in Mice
https://pubmed.ncbi.nlm.nih.gov/35886944/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acIrisin Serum Levels and Skeletal Muscle Assessment in a Cohort of Charcot-Marie-Tooth Patients
https://pubmed.ncbi.nlm.nih.gov/35634506/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acIrisin and Secondary Osteoporosis in Humans
https://pubmed.ncbi.nlm.nih.gov/35054874/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acSystemic Administration of Recombinant Irisin Accelerates Fracture Healing in Mice
https://pubmed.ncbi.nlm.nih.gov/34639200/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acThe Novel Role of PGC1α in Bone Metabolism
https://pubmed.ncbi.nlm.nih.gov/33925111/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acThe Myokine Irisin Promotes Osteogenic Differentiation of Dental Bud-Derived MSCs
https://pubmed.ncbi.nlm.nih.gov/33916859/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acIn Reply to the Letter to the Editor: Involvement of Irisin in Age-Related Osteoporosis and Its Inhibitory Effect on the Senescent Marker p21 in Osteoblasts
https://pubmed.ncbi.nlm.nih.gov/33600620/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acCorrigendum to: The role of hyperhomocysteinemia as well as folate, vitamin B6 and B12 deficiencies in osteoporosis - a systematic review
https://pubmed.ncbi.nlm.nih.gov/33554504/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acThe effect of Irisin on bone cells in vivo and in vitro
https://pubmed.ncbi.nlm.nih.gov/33449117/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acIrisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts
https://pubmed.ncbi.nlm.nih.gov/33053231/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acIrisin prevents microgravity-induced impairment of osteoblast differentiation in vitro during the space flight CRS-14 mission
https://pubmed.ncbi.nlm.nih.gov/32539174/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acMyokines and Osteokines in the Pathogenesis of Muscle and Bone Diseases
https://pubmed.ncbi.nlm.nih.gov/32514668/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acPregnancy and lactation, a challenge for the skeleton
https://pubmed.ncbi.nlm.nih.gov/32438342/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acLIGHT/TNFSF14 regulates estrogen deficiency-induced bone loss
https://pubmed.ncbi.nlm.nih.gov/31990039/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acIrisin promotes growth, migration and matrix formation in human periodontal ligament cells
https://pubmed.ncbi.nlm.nih.gov/31869727/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acOxytocin regulates body composition
https://pubmed.ncbi.nlm.nih.gov/31843930/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acIrisin Prevents Disuse-Induced Osteocyte Apoptosis
https://pubmed.ncbi.nlm.nih.gov/31826311/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acLIGHT/TNFSF14 Promotes Osteolytic Bone Metastases in Non-small Cell Lung Cancer Patients
https://pubmed.ncbi.nlm.nih.gov/31826304/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acEffects of Sweet Cherry Polyphenols on Enhanced Osteoclastogenesis Associated With Childhood Obesity
https://pubmed.ncbi.nlm.nih.gov/31130968/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acMechanisms Involved in Childhood Obesity-Related Bone Fragility
https://pubmed.ncbi.nlm.nih.gov/31130918/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acIrisin and Bone: From Preclinical Studies to the Evaluation of Its Circulating Levels in Different Populations of Human Subjects
https://pubmed.ncbi.nlm.nih.gov/31091695/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acStemness genes expression in naïve vs. osteodifferentiated human dental-derived stem cells
https://pubmed.ncbi.nlm.nih.gov/31002142/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acA Novel Interplay Between Irisin and PTH: From Basic Studies to Clinical Evidence in Hyperparathyroidism
https://pubmed.ncbi.nlm.nih.gov/30759249/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acIrisin serum levels are positively correlated with bone mineral status in a population of healthy children
https://pubmed.ncbi.nlm.nih.gov/30683930/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acLIGHT/TNFSF14 as a New Biomarker of Bone Disease in Multiple Myeloma Patients Experiencing Therapeutic Regimens
https://pubmed.ncbi.nlm.nih.gov/30405638/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acErratum to "Vitamin D Promotes MSC Osteogenic Differentiation Stimulating Cell Adhesion and αVβ3 Expression"
https://pubmed.ncbi.nlm.nih.gov/30363736/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acAn update on the role of RANKL-RANK/osteoprotegerin and WNT-ß-catenin signaling pathways in pediatric diseases
https://pubmed.ncbi.nlm.nih.gov/30343446/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acDeletion of the Transcription Factor PGC-1α in Mice Negatively Regulates Bone Mass
https://pubmed.ncbi.nlm.nih.gov/30094757/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acIrisin Serum Levels in Metabolic Syndrome Patients Treated with Three Different Diets: A Post-Hoc Analysis from a Randomized Controlled Clinical Trial
https://pubmed.ncbi.nlm.nih.gov/29958455/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acVitamin D Promotes MSC Osteogenic Differentiation Stimulating Cell Adhesion and αVβ3 Expression
https://pubmed.ncbi.nlm.nih.gov/29681950/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acHigh irisin levels are associated with better glycemic control and bone health in children with Type 1 diabetes
https://pubmed.ncbi.nlm.nih.gov/29679630/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acHigh expression of TRAIL by osteoblastic differentiated dental pulp stem cells affects myeloma cell viability
https://pubmed.ncbi.nlm.nih.gov/29484421/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acSuppressive effects of tenofovir disoproxil fumarate, an antiretroviral prodrug, on mineralization and type II and type III sodium-dependent phosphate transporters expression in primary human osteoblasts
https://pubmed.ncbi.nlm.nih.gov/29363823/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acIrisin levels correlate with bone mineral density in soccer players
https://pubmed.ncbi.nlm.nih.gov/29181953/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acImpairment of Bone Remodeling in LIGHT/TNFSF14-Deficient Mice
https://pubmed.ncbi.nlm.nih.gov/29178458/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acMonoclonal antibodies for treating osteoporosis
https://pubmed.ncbi.nlm.nih.gov/29113523/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acIrisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice
https://pubmed.ncbi.nlm.nih.gov/28588307/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acIrisin and musculoskeletal health
https://pubmed.ncbi.nlm.nih.gov/28437576/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acHigh Sclerostin and Dickkopf-1 (DKK-1) Serum Levels in Children and Adolescents With Type 1 Diabetes Mellitus
https://pubmed.ncbi.nlm.nih.gov/28388723/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acSclerostin stimulates angiogenesis in human endothelial cells
https://pubmed.ncbi.nlm.nih.gov/28267633/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293acVitamin D Effects on Osteoblastic Differentiation of Mesenchymal Stem Cells from Dental Tissues
https://pubmed.ncbi.nlm.nih.gov/27956902/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1fGBqCW25OtLvOKbEsNM1TLhvNhjsSGzp9gh884z8Dmd3VbQzB&fc=None&ff=20230923015117&v=2.17.9.post6+86293ac