Academic Title: Dr
First Name: Katharina
Last Name: Jähn-Rickert
Academic Degree: PhD
Member Since: May 2020
Institution: University Medical Center Hamburg-Eppendorf
Katharina Jähn-Rickert, PhD is a principal investigator at the Department of Osteology and Biomechanics at the University Medical Center Hamburg-Eppendorf, D.
Her work focuses on the functional investigation of osteocytes in bone physiology and pathologies utilizing state-of-the-art imaging approaches – thereby she aims to work on the interface of different disciplines i.e. biomechanics, molecular, clinical, and translational research.
Initially, she studied Biochemistry in Leipzig, D and went on to do her Ph.D. with Cardiff University, UK and the AO Research Institute Davos, CH.
Within a European Space Agency funded project, she investigated the impact of ex vivo bone organ culture on osteocyte viability, and the potential of high frequency low amplitude loading to prevent microgravity-induced bone loss.
During her post-doctoral work at the University of Missouri-Kansas City, USA, she demonstrated that soluble factors from skeletal muscles are beneficial to osteocyte viability, and further showed that osteocytes can acidify their microenvironment during lactation-induced osteocytic osteolysis in mice.
In Hamburg she also contributed to the description of a novel regulator of bone remodeling, while also demonstrating that a new magnesium-silver-alloy implant enabled physiological fracture healing in a collaborative effort with the Helmholtz Center, D.
- 01/09/2018IFMRS Fellowship Award
- 18/07/2012ASBMR Young Investigator Award
- 01/11/2019Marie Sklodowska-Curie Initial Training Network Grant
- 01/11/2018German Research Foundation Individual Grant
List of invited presentations
- 01/03/2019Autocrine/Paracrine Regulation of the Skeleton by PTHrP at the DGE in Germany
- 01/03/2017The osteocyte - Mechanotransduction and interaction with the musculature at the Osteology in Germany
- 02/03/2017The osteocyte and FGF23 at the DGE in Germany
- 02/05/2016Bone and muscle: interactions beyond mechanical at the ECTS in Italy
- 01/03/2015Interaction between Osteocytes and Muscle Cells at the Osteology in Germany
- 01/06/2013Bone cells - Osteocytes at the ECTS PhD Training Course in Germany
List of 5 Best Publications
- Elevated Bone Hardness Under Denosumab Treatment, With Persisting Lower Osteocyte Viability During Discontinuationhttps://www.frontiersin.org/articles/10.3389/fendo.2020.00250/full
- Multiscale bone quality analysis in osteoarthritic knee joints reveal a role of the mechanosensory osteocyte network in osteophyteshttps://www.nature.com/articles/s41598-019-57303-z
- TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormonehttps://www.nature.com/articles/s41467-019-08778-x
- Osteocytes Acidify Their Microenvironment in Response to PTHrP In Vitro and in Lactating Mice In Vivohttps://asbmr.onlinelibrary.wiley.com/doi/full/10.1002/jbmr.3167
- Skeletal muscle secreted factors prevent glucocorticoid-induced osteocyte apoptosis through activation of β-cateninhttps://www.ecmjournal.org/papers/vol024/pdf/v024a14.pdf