Academic Title: PhD
First Name: Katherine
Last Name: Staines
Member Since: May 2017
City: Brighton
Institution: University of Brighton (UK)


Katherine Staines received her PhD from the University of Edinburgh (UK) in 2012. Her PhD studies identified new regulators of growth plate mineralisation

Katherine completed two postdoctoral positions, the first of which was at the Royal Veterinary College, London UK. During this position, Katherine examined the contribution of articular cartilage chondrocyte phenotype and mineralisation to osteoarthritis pathology. Using novel synchrotron-based methods, temporospatial associations were made between aberrant longitudinal bone growth and mechanisms underpinning pathological ossification in osteoarthritis.

Katherine’s interest in osteoarthritis continued in her second postdoctoral position at the Roslin Institute, University of Edinburgh. Here she examined the role of the glyocoprotein E11 in osteocyte formation and the contribution of this to osteoarthritis pathology, through the development of a novel conditional knockout mouse.

Katherine is currently a Vice Chancellor's Research Fellow at Edinburgh Napier University. Her research is focused on the development, regulation and pathology of the musculoskeletal system, still with a focus on osteoarthritis. Katherine is the New Investigator representative for the Bone Research Society and currently sits on the Editorial Board for the Journal of Endocrinology, the Journal of Molecular Endocrinology, BMC musculoskeletal disorders, and Frontiers in Endocrinology, Bone Research.


  • 28/06/2017New Investigator Award for highest scoring abstracts, Bone Research Society Annual Conference
  • 28/06/2016New Investigator Award for highest scoring abstracts, Bone Research Society Annual Conference
  • 28/03/2016ASBMR John Haddad New Investigator Award
  • 28/03/2016Bone Research Society AIMM-ASBMR award
  • 28/06/2012New investigator award, Osteoporosis and Bone Conference
  • 21/06/2017Staff Presentation Award, Edinburgh Napier University Research Conference


  • Medical Research Council. UK Nutrition Research Partnership. Call: Nutrition Hot Topic Workshops. Vitamin D – a multi-disciplinary approach. £9.5k (PI)
  • Medical Research Council. Osteoarthritis: Going back to basics. £432k (PI)
  • Medical Research Scotland. Development of a novel 3D culture system to understand bone:cartilage crosstalk in osteoarthritis. £116k (PI)
  • Medical Research Council. Imaging dynamics in biophysical/biochemical processes across the hierarchical scales – BioPro Network. £664k (co-PI)
  • Dr. Lawrence Ho Research and Development Fund. Investigating new therapies for osteoarthritis. £30k (PI)
  • Edinburgh Napier University Vice Chancellor’s Research Fellowship. Understanding musculoskeletal ageing. £250k (PI)
  • Society for Endocrinology. Does deregulated PHOSPHO1 expression contribute to catabolic bone loss in hyper-parathyroid hormone disorders? £2850 (co-PI)
  • Medical Research Scotland. Does deregulated PHOSPHO1 expression contribute to catabolic bone loss in hyper-parathyroid hormone disorders? £2k (co-PI)
  • Tenovus Scotland. Investigating new therapeutic strategies for osteoarthritis. £12k (PI)
  • Society for Endocrinology. Generation of sclerostin knockout mice to examine sclerostin\'s functional role in endochondral bone growth and osteoarthritis. £10k (PI)
  • European Calcified Tissue Society. In situ hybridisation of MEPE in the murine growth plate; laboratory visit to Imperial College London. €2.5k (PI)

List of invited presentations

  • Sclerostin: An innate protector against osteoarthritic bone pathology. Royal Veterinary College, London (2012)
  • Understanding pathological ossification in osteoarthritis; a major healthcare burden in the ageing population. EastBio Ageing symposium, Edinburgh (2015)
  • Pathological ossification in osteoarthritis. University of Sheffield (2016)
  • MicroCT analysis of subchondral bone thickening in osteoarthritis. University of Sheffield (2016)
  • Understanding pathological ossification in osteoarthritis. AIMM-ASBMR Young Investigators Meeting, Colorado USA (2016)
  • Understanding pathological ossification in osteoarthritis. University of Brighton (2016)
  • Public Engagement for health sciences. EastBio Health symposium, Edinburgh (2016)
  • Understanding pathological ossification in osteoarthritis. IGMM, University of Edinburgh (2018)
  • Understanding pathological ossification in osteoarthritis, Manchester Met (2018)
  • Dynamic synchrotron imaging of osteoarthritic joints, Edinburgh Musculoskeletal Group Winter symposium (2018)
  • Novel Insights into Growth Plate Fusion, ESPE (2019)
  • Mechanoadaptation of joint development, Bone Research Society (2021

List of 5 Best Publications

  • In situ characterisation of nano-scale strains in a physiologically-representative whole joint loading modelMadi K*/Staines K.A*., Bay B.K., Geng H., Bodey A.J., Javaheri B., Cartmell S., Pitsillides A.A., Lee P.D.
  • Azathioprine has a deleterious effect on the bone health of mice with DSS-induced inflammatory bowel disease.Morgan S., Hooper K.M., Milne E., Farquharson C., Stevens C., Staines K.A.
  • Hypomorphic conditional deletion of E11/podoplanin protects against load-induced osteoarthritis.Staines K.A., Ikpegbu E., Tornqvist A., Javaheri B., Amin A.K., Clements D.N., Buttle D.J., Pitsillides A.A., Farquharson C.
  • Life course longitudinal growth and risk of knee osteoarthritis at age 53 years: evidence from the 1946 British birth cohort study. Staines K.A., Hardy R.J., Samvelyan H.J., Ward K.A., Cooper R.
  • Endochondral growth defects and deployment of transient chondrocyte behaviours in articular cartilage characterise onset of osteoarthritis in a natural murine modelStaines K.A., Madi K., Mirczuk S.M., Parker S., Burleigh A., Poulet B., Hopkinson M., Bodey A.J., Fowkes R.C., Farquharson C., Lee P.D., Pitsillides A.A.


- Areas Of Expertise: Ageing, Computer Tomography, Epidemiology, Growth Plate, Histology, Histomorphometry, Imaging, In Vivo Models, Mineralisation, Molecular Biology, and Osteoarthritis
- Favorite Cell: Osteocyte
- Favorite Protein: E11
- Best technical skill: Immunohistochemistry
- Best knowledge: Endochondral ossification and osteoarthritis
- Research goal: To understand the mechanisms underpinning osteoarthritis
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- Favorite quote: Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less (Marie Curie)