Biography
Ling Oei received her MD from Leiden University in 2009 and her PhD from Erasmus University in 2016. She was a post-doctoral scholar at Stanford University in 2013. She assisted Dr. M.C. Zillikens as a clinical resident in the Erasmus MC's Bone Centre and started internist-endocrinologist training in 2014. She has co-led large-scale consortia projects for genome-wide association studies of osteoporosis describing discovery of over seventy loci for osteoporosis(-related traits) and fracture risk.
Her epidemiological studies look into bone disease subtypes and deeper characterisation of processes underlying fractures, including bone disease in type 2 diabetes mellitus.
The radiological scoring of osteoporotic vertebral fractures in the Rotterdam Study has uncovered huge differences between methods. The landmark paper appeared in the Journal of Bone and Mineral Research. Concomitantly, she has started systematic assessments for non-fracture deformities for optimisation of quality and efficiency of vertebral assessments.
She has also successfully applied findings to individual clinical patients and found wrongly diagnosed vertebral fractures or genetic causes for osteoporosis requiring different medical management, as published in case series.
Currently, dr. Oei is employed as an internal medicine-endocrinology fellow in-training and assistant professor at Erasmus MC, Rotterdam, The Netherlands
List of 5 Best Publications
Reference Values for Paravertebral Muscle Size and Myosteatosis in Chinese Adults, a Nationwide Multicenter Study
https://pubmed.ncbi.nlm.nih.gov/38494349/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414A dens fracture case solved
https://pubmed.ncbi.nlm.nih.gov/38331403/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations
https://pubmed.ncbi.nlm.nih.gov/38200577/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Association of Bone Mineral Density and Dementia: The Rotterdam Study
https://pubmed.ncbi.nlm.nih.gov/36948596/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414The effect of osteoporosis treatment on bone mass
https://pubmed.ncbi.nlm.nih.gov/35219602/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Bone Phenotyping Approaches in Human, Mice and Zebrafish - Expert Overview of the EU Cost Action GEMSTONE ("GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork")
https://pubmed.ncbi.nlm.nih.gov/34925226/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414The Treatment Gap in Osteoporosis
https://pubmed.ncbi.nlm.nih.gov/34279485/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Type 2 Diabetes Mellitus and Vertebral Fracture Risk
https://pubmed.ncbi.nlm.nih.gov/33432548/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Vertebral Fractures in Individuals With Type 2 Diabetes: More Than Skeletal Complications Alone
https://pubmed.ncbi.nlm.nih.gov/31658976/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Recent Advances in the Genetics of Fractures in Osteoporosis
https://pubmed.ncbi.nlm.nih.gov/31231309/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414The Radiology of Osteoporotic Vertebral Fractures Revisited
https://pubmed.ncbi.nlm.nih.gov/30645770/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study
https://pubmed.ncbi.nlm.nih.gov/30158200/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Response to Osteoporotic Vertebral Fracture Prevalence Varies Widely
https://pubmed.ncbi.nlm.nih.gov/30011100/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Fracture incidence and secular trends between 1989 and 2013 in a population based cohort: The Rotterdam Study
https://pubmed.ncbi.nlm.nih.gov/29885926/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Vertebral Fractures and Morphometric Deformities
https://pubmed.ncbi.nlm.nih.gov/29750843/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness
https://pubmed.ncbi.nlm.nih.gov/29313844/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density
https://pubmed.ncbi.nlm.nih.gov/29170203/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Osteoporotic Vertebral Fracture Prevalence Varies Widely Between Qualitative and Quantitative Radiological Assessment Methods: The Rotterdam Study
https://pubmed.ncbi.nlm.nih.gov/28719143/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Quantitative imaging methods in osteoporosis
https://pubmed.ncbi.nlm.nih.gov/28090446/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2
https://pubmed.ncbi.nlm.nih.gov/27476799/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Reninoma: A Rare Cause of Curable Hypertension and Hypokalemia
https://pubmed.ncbi.nlm.nih.gov/27103051/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX
https://pubmed.ncbi.nlm.nih.gov/26498132/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Genetics of Osteoporotic Vertebral Fractures
https://pubmed.ncbi.nlm.nih.gov/26376172/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Osteoporotic Vertebral Fractures as Part of Systemic Disease
https://pubmed.ncbi.nlm.nih.gov/26376171/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture
https://pubmed.ncbi.nlm.nih.gov/26367794/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414The Association between Metabolic Syndrome, Bone Mineral Density, Hip Bone Geometry and Fracture Risk: The Rotterdam Study
https://pubmed.ncbi.nlm.nih.gov/26066649/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414New genetic loci link adipose and insulin biology to body fat distribution
https://pubmed.ncbi.nlm.nih.gov/25673412/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Diabetes, diabetic complications, and fracture risk
https://pubmed.ncbi.nlm.nih.gov/25648962/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Personalized sequencing and the future of medicine: discovery, diagnosis and defeat of disease
https://pubmed.ncbi.nlm.nih.gov/25493570/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment
https://pubmed.ncbi.nlm.nih.gov/24945404/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Bone mineral density and chronic lung disease mortality: the rotterdam study
https://pubmed.ncbi.nlm.nih.gov/24606086/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Genome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 BMD locus
https://pubmed.ncbi.nlm.nih.gov/24516880/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Scheuermann disease: evaluation of radiological criteria and population prevalence
https://pubmed.ncbi.nlm.nih.gov/24509552/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium
https://pubmed.ncbi.nlm.nih.gov/24430505/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Osteoporotic vertebral fractures during pregnancy: be aware of a potential underlying genetic cause
https://pubmed.ncbi.nlm.nih.gov/24423337/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus
https://pubmed.ncbi.nlm.nih.gov/24343915/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Multi-functionality of computer-aided quantitative vertebral fracture morphometry analyses
https://pubmed.ncbi.nlm.nih.gov/24273742/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: the Rotterdam Study
https://pubmed.ncbi.nlm.nih.gov/23315602/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Review of radiological scoring methods of osteoporotic vertebral fractures for clinical and research settings
https://pubmed.ncbi.nlm.nih.gov/22892721/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Assessment of gene-by-sex interaction effect on bone mineral density
https://pubmed.ncbi.nlm.nih.gov/22692763/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
https://pubmed.ncbi.nlm.nih.gov/22504420/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies
https://pubmed.ncbi.nlm.nih.gov/22451239/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414Bexarotene induces dyslipidemia by increased very low-density lipoprotein production and cholesteryl ester transfer protein-mediated reduction of high-density lipoprotein
https://pubmed.ncbi.nlm.nih.gov/19147676/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20241018021258&v=2.18.0.post9+e462414