Biography
Ling Oei received her MD from Leiden University in 2009 and her PhD from Erasmus University in 2016. She was a post-doctoral scholar at Stanford University in 2013. She assisted Dr. M.C. Zillikens as a clinical resident in the Erasmus MC's Bone Centre and started internist-endocrinologist training in 2014. She has co-led large-scale consortia projects for genome-wide association studies of osteoporosis describing discovery of over seventy loci for osteoporosis(-related traits) and fracture risk.
Her epidemiological studies look into bone disease subtypes and deeper characterisation of processes underlying fractures, including bone disease in type 2 diabetes mellitus.
The radiological scoring of osteoporotic vertebral fractures in the Rotterdam Study has uncovered huge differences between methods. The landmark paper appeared in the Journal of Bone and Mineral Research. Concomitantly, she has started systematic assessments for non-fracture deformities for optimisation of quality and efficiency of vertebral assessments.
She has also successfully applied findings to individual clinical patients and found wrongly diagnosed vertebral fractures or genetic causes for osteoporosis requiring different medical management, as published in case series.
Currently, dr. Oei is employed as an internal medicine-endocrinology fellow in-training and assistant professor at Erasmus MC, Rotterdam, The Netherlands
List of 5 Best Publications
Association of Bone Mineral Density and Dementia: The Rotterdam Study
https://pubmed.ncbi.nlm.nih.gov/36948596/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acThe effect of osteoporosis treatment on bone mass
https://pubmed.ncbi.nlm.nih.gov/35219602/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acBone Phenotyping Approaches in Human, Mice and Zebrafish - Expert Overview of the EU Cost Action GEMSTONE ("GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork")
https://pubmed.ncbi.nlm.nih.gov/34925226/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acThe Treatment Gap in Osteoporosis
https://pubmed.ncbi.nlm.nih.gov/34279485/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acType 2 Diabetes Mellitus and Vertebral Fracture Risk
https://pubmed.ncbi.nlm.nih.gov/33432548/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acVertebral Fractures in Individuals With Type 2 Diabetes: More Than Skeletal Complications Alone
https://pubmed.ncbi.nlm.nih.gov/31658976/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acRecent Advances in the Genetics of Fractures in Osteoporosis
https://pubmed.ncbi.nlm.nih.gov/31231309/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acThe Radiology of Osteoporotic Vertebral Fractures Revisited
https://pubmed.ncbi.nlm.nih.gov/30645770/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acAssessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study
https://pubmed.ncbi.nlm.nih.gov/30158200/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acResponse to Osteoporotic Vertebral Fracture Prevalence Varies Widely
https://pubmed.ncbi.nlm.nih.gov/30011100/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acFracture incidence and secular trends between 1989 and 2013 in a population based cohort: The Rotterdam Study
https://pubmed.ncbi.nlm.nih.gov/29885926/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acVertebral Fractures and Morphometric Deformities
https://pubmed.ncbi.nlm.nih.gov/29750843/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acLarge-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness
https://pubmed.ncbi.nlm.nih.gov/29313844/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acIdentification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density
https://pubmed.ncbi.nlm.nih.gov/29170203/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acOsteoporotic Vertebral Fracture Prevalence Varies Widely Between Qualitative and Quantitative Radiological Assessment Methods: The Rotterdam Study
https://pubmed.ncbi.nlm.nih.gov/28719143/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acQuantitative imaging methods in osteoporosis
https://pubmed.ncbi.nlm.nih.gov/28090446/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acNovel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2
https://pubmed.ncbi.nlm.nih.gov/27476799/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acReninoma: A Rare Cause of Curable Hypertension and Hypokalemia
https://pubmed.ncbi.nlm.nih.gov/27103051/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acA Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX
https://pubmed.ncbi.nlm.nih.gov/26498132/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acGenetics of Osteoporotic Vertebral Fractures
https://pubmed.ncbi.nlm.nih.gov/26376172/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acOsteoporotic Vertebral Fractures as Part of Systemic Disease
https://pubmed.ncbi.nlm.nih.gov/26376171/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acWhole-genome sequencing identifies EN1 as a determinant of bone density and fracture
https://pubmed.ncbi.nlm.nih.gov/26367794/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acThe Association between Metabolic Syndrome, Bone Mineral Density, Hip Bone Geometry and Fracture Risk: The Rotterdam Study
https://pubmed.ncbi.nlm.nih.gov/26066649/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acNew genetic loci link adipose and insulin biology to body fat distribution
https://pubmed.ncbi.nlm.nih.gov/25673412/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acDiabetes, diabetic complications, and fracture risk
https://pubmed.ncbi.nlm.nih.gov/25648962/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acPersonalized sequencing and the future of medicine: discovery, diagnosis and defeat of disease
https://pubmed.ncbi.nlm.nih.gov/25493570/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acPhenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment
https://pubmed.ncbi.nlm.nih.gov/24945404/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acBone mineral density and chronic lung disease mortality: the rotterdam study
https://pubmed.ncbi.nlm.nih.gov/24606086/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acGenome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 BMD locus
https://pubmed.ncbi.nlm.nih.gov/24516880/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acScheuermann disease: evaluation of radiological criteria and population prevalence
https://pubmed.ncbi.nlm.nih.gov/24509552/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acGenetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium
https://pubmed.ncbi.nlm.nih.gov/24430505/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acOsteoporotic vertebral fractures during pregnancy: be aware of a potential underlying genetic cause
https://pubmed.ncbi.nlm.nih.gov/24423337/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acA genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus
https://pubmed.ncbi.nlm.nih.gov/24343915/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acMulti-functionality of computer-aided quantitative vertebral fracture morphometry analyses
https://pubmed.ncbi.nlm.nih.gov/24273742/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acHigh bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: the Rotterdam Study
https://pubmed.ncbi.nlm.nih.gov/23315602/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acReview of radiological scoring methods of osteoporotic vertebral fractures for clinical and research settings
https://pubmed.ncbi.nlm.nih.gov/22892721/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acAssessment of gene-by-sex interaction effect on bone mineral density
https://pubmed.ncbi.nlm.nih.gov/22692763/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acGenome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
https://pubmed.ncbi.nlm.nih.gov/22504420/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acAssociation between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies
https://pubmed.ncbi.nlm.nih.gov/22451239/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293acBexarotene induces dyslipidemia by increased very low-density lipoprotein production and cholesteryl ester transfer protein-mediated reduction of high-density lipoprotein
https://pubmed.ncbi.nlm.nih.gov/19147676/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1x1PPzbhojr6gl1I5YDjR5cr0R25Z958hkKPfSLwX_QiwokQ4a&fc=None&ff=20230922154453&v=2.17.9.post6+86293ac