Biography

I am a Sir Henry Dale Fellow and head of the Integrative Skeletal Physiology group at the Institute of Clinical Sciences, Imperial College London. My group investigates the importance of blood vessels in regulating the skeletal physiology. We use mouse as a model system to understand novel functions of blood vessels in the body.

List of 5 Best Publications

• Artificial Intelligence (AI) and Robotics in Elderly Healthcare: Enabling Independence and Quality of Life

  https://pubmed.ncbi.nlm.nih.gov/37664381/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Tyrosine kinase inhibitor therapy in pediatric sarcoma: Prognostic implications of pulmonary metastatic cavitation

  https://pubmed.ncbi.nlm.nih.gov/37580891/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Comparison of diffusion-weighted MRI and [¹⁸F]FDG PET/MRI for treatment monitoring in pediatric Hodgkin and non-Hodgkin lymphoma

  https://pubmed.ncbi.nlm.nih.gov/37542653/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• A Porphyrin-based NIR Fluorescent Probe for Bi³⁺ and Potential Applications

  https://pubmed.ncbi.nlm.nih.gov/37358757/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Response to Performance of ChatGPT on a Radiology Board-style Examination

  https://pubmed.ncbi.nlm.nih.gov/37338357/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Measurement of Tumor T2* Relaxation Times after Iron Oxide Nanoparticle Administration

  https://pubmed.ncbi.nlm.nih.gov/37318243/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Lymphatic vessels in bone support regeneration after injury

  https://pubmed.ncbi.nlm.nih.gov/36669473/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Oestrogen enforces the integrity of blood vessels in the bone during pregnancy and menopause

  https://pubmed.ncbi.nlm.nih.gov/36531334/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Ferumoxytol-Enhanced MRI in Children and Young Adults: State of the Art

  https://pubmed.ncbi.nlm.nih.gov/36197052/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Unusual presentation of adrenal hemangioma as an incidental large adrenal hematoma - A case report

  https://pubmed.ncbi.nlm.nih.gov/35149234/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging

  https://pubmed.ncbi.nlm.nih.gov/33536212/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Blood Vessels and Vascular Niches in Bone Development and Physiological Remodeling

  https://pubmed.ncbi.nlm.nih.gov/33330496/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system

  https://pubmed.ncbi.nlm.nih.gov/33215738/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Bone Vasculature and Bone Marrow Vascular Niches in Health and Disease

  https://pubmed.ncbi.nlm.nih.gov/32845550/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Angiocrine signals regulate quiescence and therapy resistance in bone metastasis

  https://pubmed.ncbi.nlm.nih.gov/31292293/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Endothelial proteolytic activity and interaction with non-resorbing osteoclasts mediate bone elongation

  https://pubmed.ncbi.nlm.nih.gov/30936475/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML

  https://pubmed.ncbi.nlm.nih.gov/29276143/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Structure and Functions of Blood Vessels and Vascular Niches in Bone

  https://pubmed.ncbi.nlm.nih.gov/29104595/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Corrigendum: Regulation of monocyte cell fate by blood vessels mediated by Notch signalling

  https://pubmed.ncbi.nlm.nih.gov/28466869/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Flow Dynamics and HSPC Homing in Bone Marrow Microvessels

  https://pubmed.ncbi.nlm.nih.gov/28199850/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Confocal/two-photon microscopy in studying colonisation of cancer cells in bone using xenograft mouse models

  https://pubmed.ncbi.nlm.nih.gov/28018584/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Blood flow controls bone vascular function and osteogenesis

  https://pubmed.ncbi.nlm.nih.gov/27922003/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Corrigendum: Age-dependent modulation of vascular niches for haematopoietic stem cells

  https://pubmed.ncbi.nlm.nih.gov/27626373/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Regulation of monocyte cell fate by blood vessels mediated by Notch signalling

  https://pubmed.ncbi.nlm.nih.gov/27576369/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Regulation of Hematopoiesis and Osteogenesis by Blood Vessel-Derived Signals

  https://pubmed.ncbi.nlm.nih.gov/27576121/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Corrigendum: Distinct bone marrow blood vessels differentially regulate haematopoiesis

  https://pubmed.ncbi.nlm.nih.gov/27437586/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Distinct bone marrow blood vessels differentially regulate haematopoiesis

  https://pubmed.ncbi.nlm.nih.gov/27074509/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Age-dependent modulation of vascular niches for haematopoietic stem cells

  https://pubmed.ncbi.nlm.nih.gov/27074508/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Sample preparation for high-resolution 3D confocal imaging of mouse skeletal tissue

  https://pubmed.ncbi.nlm.nih.gov/26513669/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Transient receptor potential channel 1 maintains adherens junction plasticity by suppressing sphingosine kinase 1 expression to induce endothelial hyperpermeability

  https://pubmed.ncbi.nlm.nih.gov/26316271/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Regulation of tissue morphogenesis by endothelial cell-derived signals

  https://pubmed.ncbi.nlm.nih.gov/25529933/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

  https://pubmed.ncbi.nlm.nih.gov/24647000/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

  https://pubmed.ncbi.nlm.nih.gov/24646994/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Molecular cloning, expression, and in silico structural analysis of guinea pig IL-17

  https://pubmed.ncbi.nlm.nih.gov/23813049/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Notch exhibits ligand bias and maneuvers stage-specific steering of neural differentiation in embryonic stem cells

  https://pubmed.ncbi.nlm.nih.gov/20154142/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Structure of the twin-arginine signal-binding protein DmsD from Escherichia coli

  https://pubmed.ncbi.nlm.nih.gov/19652330/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice

  https://pubmed.ncbi.nlm.nih.gov/19498056/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Terminal end bud maintenance in mammary gland is dependent upon FGFR2b signaling

  https://pubmed.ncbi.nlm.nih.gov/18381212/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Neural induction from ES cells portrays default commitment but instructive maturation

  https://pubmed.ncbi.nlm.nih.gov/18092007/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Arp3 is required during preimplantation development of the mouse embryo

  https://pubmed.ncbi.nlm.nih.gov/18035060/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

• Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development

  https://pubmed.ncbi.nlm.nih.gov/17560563/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1FAuRRws3kelNWY1KeJqdPM_BJ-oRjZa-kjHj64fIUA6t1WEcB&fc=None&ff=20230922114708&v=2.17.9.post6+86293ac

STRENGTH AND WEAKNESSES AT WORK

- Favorite Cell: Endothelium

- Favorite Protein: Notch

- Best technical skill: Imaging

- Best knowledge: Bone Vasculature

- Research goal: To explore the therapeutic potential of blood vessels

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PERSONAL STRENGTH AND WEAKNESSES

- Favorite place to live: Home

- Best sport skill: Football

- Worst performance: Playing Music

- Free time activity: Listening to music

- Favorite quote: Many…varies with the situation.